Ciurczak Course Details

Introduction to Near-Infrared Spectroscopy: Applications in the

Pharmaceutical Industry 

One-Day Course E10-27, Tuesday, November 16, 2010, 8:30am – 5:30pm

Dr. Emil Ciurczak, Independent Consultant, Goldens Bridge, NY 



Near-Infrared Spectroscopy (NIRS) is a non-destructive, rapid method for determining both chemical and physical properties of 

pure materials (API and excipients), packaging materials, mixtures, solutions, and solid dosage forms. This course will review the

theory and equipment used in NIR, the most common software packages, and some qualitative and quantitative applications. 



This course is a good introduction to analysts, lab managers, QA/QC personnel, and any person involved with process analysis

(PAT/ QbD). The course will benefit anyone considering NIR as a tool as well as analysts already performing NIR analyses. Attendees

need not be a spectroscopist to benefit from the course. 



Basic theory and history 

A brief history and theory 

• Why NIR is different from “classic” spectrometric methods 

• What can be seen and where NIR may not be best applied 

Hardware Available 

Interference and linear variable filters 

• Gratings 

• Interferometers 

• Acousto-Optic Tunable Filters 


• Strengths and weaknesses of each, and where each would be best applied 

Software and Chemometrics 

• Multiple Linear Regression (MLR) 

• Principal Components Analysis (PCA) 

• Partial Least Squares (PLS) 

• Mahalanobis Distances, Conformity Index, Spectral Matching 

• Some 3rd party software available 

Qualitative Applications 

• Raw material ID/qualification (RMID) 

• Clinical Trials/Counterfeiting 

• Polymorphic changes 

• Blend uniformity 

Quantitative Applications 

• Moisture (RM, drying, Lyophilization) 

• % polymorph 

• % crystallinity 



Handbook of Near-Infrared Analysis/, 3rd Edition, Burns and Ciurczak, eds., CRC Press, 2007 




Dr. Emil Ciurczak has degrees in chemistry from Rutgers and Seton Hall Universities and worked in the Pharma industry since 

1970 at Ciba-Geigy, Cooper Labs (Berlex), Sandoz, Merck, and Purdue Pharma. He has also worked with or consulted for Technicon 

(Bran+Leubbe), FOSS NIRSystems, Brimrose, Infrared Fiber Systems, and Control Development. Emil introduced NIR at Sandoz in 1983 

and was checking all raw materials (100% container-wise testing) by 1985. 

He is now an independent consultant, performing NIR, PAT and QbD applications and teaching courses in PAT and NIR in the US and 

Europe; he was the 2004 recipient of the EAS NIR Award. Emil holds nine patents for NIR equipment and software. 

Emil is co-author of “The Handbook of NIR Analysis” (3 editions) and “Medical and Pharmaceutical Applications of NIR.” He was a contributing 

editor to Spectroscopy from 1988 to 2005, and is presently Contributing Editor for Pharmaceutical Manufacturing magazine. He 

has published over 75 papers and has over 150 presented papers